William M Abraham Selected Research

PF-5212372

3/2012

Preclinical evaluation of an inhibitor of cytosolic phospholipase A2α for the treatment of asthma.

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William M Abraham Research Topics

Disease

22	Asthma (Bronchial Asthma) 02/2016 - 07/2002
16	Respiratory Hypersensitivity 10/2015 - 07/2002
14	Inflammation (Inflammations) 01/2020 - 02/2002
8	Cystic Fibrosis (Mucoviscidosis) 01/2020 - 12/2004
8	Lung Diseases (Lung Disease) 01/2019 - 01/2004
5	Chronic Obstructive Pulmonary Disease (COPD) 06/2013 - 06/2007
4	Hemorrhage 05/2013 - 04/2008
4	Hypersensitivity (Allergy) 05/2010 - 01/2003
3	Allergic Rhinitis 10/2015 - 10/2008
3	Hypovolemia 05/2013 - 04/2008
3	Acidosis 05/2013 - 06/2009
2	Pneumonia (Pneumonitis) 06/2013 - 02/2010
2	Hemorrhagic Shock 05/2013 - 06/2009
2	Shock 03/2010 - 04/2008
1	Anaphylaxis (Anaphylactic Shock) 12/2013
1	Dehydration (Water Stress) 06/2013
1	Reperfusion Injury 05/2013
1	Heart Arrest (Cardiac Arrest) 05/2013
1	Atopic Dermatitis (Atopic Eczema) 01/2011
1	Necrosis 03/2010
1	Pancreatic Diseases (Pancreatic Disease) 08/2008
1	Edema (Dropsy) 02/2008
1	Fibrosis (Cirrhosis) 03/2007

Drug/Important Bio-Agent (IBA)

16	AntigensIBA 10/2015 - 07/2002
7	AllergensIBA 02/2016 - 01/2004
5	Carbachol (Carbastat)FDA Link 04/2013 - 07/2002
4	Leukocyte Elastase (Neutrophil Elastase)IBA 01/2019 - 12/2002
4	Epithelial Sodium ChannelsIBA 01/2017 - 12/2004
4	Oxygen (Dioxygen)IBA 01/2013 - 04/2008
4	AerosolsIBA 02/2010 - 08/2003
3	Sodium-Hydrogen ExchangersIBA 01/2013 - 06/2009
2	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 01/2017 - 08/2008
2	Anti-Allergic Agents (Antiallergic Agents)IBA 06/2014 - 04/2013
2	Proteins (Proteins, Gene)FDA Link 05/2013 - 01/2013
2	EnzymesIBA 03/2012 - 01/2011
2	Serine Proteases (Serine Protease)IBA 02/2010 - 04/2004
2	methanesulfonic acid (methanesulfonate)IBA 04/2008 - 04/2008
2	Amiloride (Midamor)FDA LinkGeneric 04/2008 - 12/2004
2	Tryptases (Tryptase)IBA 03/2008 - 02/2002
2	Immunoglobulin G (IgG)IBA 03/2007 - 01/2004
2	Integrin alpha4beta1 (VLA-4)IBA 06/2006 - 07/2002
2	Monoclonal AntibodiesIBA 03/2005 - 01/2004
1	Angiotensin Receptors (Angiotensin II Receptor)IBA 01/2020
1	Leucine (L-Leucine)FDA Link 01/2020
1	Losartan (Cozaar)FDA LinkGeneric 01/2020
1	Large-Conductance Calcium-Activated Potassium Channels (Maxi-K Channels)IBA 01/2020
1	Nitric Oxide Synthase (NO Synthase)IBA 01/2019
1	NG-Nitroarginine Methyl Ester (L-NAME)IBA 01/2019
1	Peptides (Polypeptides)IBA 01/2018
1	SteroidsIBA 02/2016
1	KininsIBA 02/2016
1	asapiprantIBA 10/2015
1	MucinsIBA 10/2015
1	Silver Sulfadiazine (SSD)FDA LinkGeneric 06/2014
1	heparin disaccharideIBA 06/2014
1	Syk KinaseIBA 12/2013
1	2'-desoxy-9-erythromycylamineIBA 06/2013
1	Anti-Bacterial Agents (Antibiotics)IBA 06/2013
1	MacrolidesIBA 06/2013
1	sabiporideIBA 01/2013
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2013
1	Prostaglandins DIBA 03/2012
1	Pharmaceutical PreparationsIBA 03/2012
1	Adenosine Monophosphate (AMP)IBA 03/2012
1	Phospholipases (Phospholipase)IBA 03/2012
1	EicosanoidsIBA 03/2012
1	PF-5212372IBA 03/2012
1	OligosaccharidesIBA 01/2012
1	ProstaglandinsIBA 01/2011
1	Formyl Peptide Receptors (Formyl Peptide Receptor)IBA 01/2011
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2011
1	((7R)- 7- (((4- fluorophenyl)sulfonyl)(methyl)amino)- 6,7,8,9- tetrahydropyrido(1,2- a)indol- 10- yl)acetic acidIBA 01/2011
1	Adrenergic Agents (Adrenergic Drugs)IBA 12/2010
1	Adrenergic beta-Agonists (beta-Adrenergic Agonists)IBA 12/2010
1	Prostaglandin H2 (PGH(2))IBA 05/2010
1	Prostaglandin D2IBA 05/2010
1	Interleukin-6 (Interleukin 6)IBA 03/2010
1	Peroxidase (Myeloperoxidase)IBA 03/2010
1	JNJ-10311795IBA 02/2010
1	Chymases (Chymase)IBA 02/2010
1	SmokeIBA 02/2010
1	Cathepsin GIBA 02/2010
1	brevetoxinIBA 07/2009
1	Hydroxyethyl Starch Derivatives (Pentastarch)FDA Link 06/2009
1	Guanidine (Guanidine Nitrate)FDA Link 04/2008
1	benzamideIBA 04/2008
1	CarrageenanIBA 02/2008
1	anrukinzumabIBA 03/2007
1	Interleukin-13IBA 03/2007
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2006
1	L-SelectinIBA 03/2005
1	LigandsIBA 03/2005
1	Tissue Kallikreins (Tissue Kallikrein)IBA 04/2004
1	KallidinIBA 04/2004

Therapy/Procedure

8	Therapeutics 01/2020 - 04/2004
4	Resuscitation 05/2013 - 04/2008
1	Microspheres (Microsphere) 05/2013
1	Catheters 05/2013
1	Aftercare (After-Treatment) 04/2013
1	Intravenous Administration 03/2005